3-ethyl-4,5-dimethyl-1H-pyrrole-2-carboxylic Acid → 2-Chloro-6-(4-{[(3-ethyl-4,5-dimethyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)isonicotinamide
反応式
Cl.[NH2:2][CH:3]1[CH2:8][CH2:7][N:6]([C:9]2[CH:10]=[C:11]([CH:15]=[C:16]([Cl:18])[N:17]=2)[C:12]([NH2:14])=[O:13])[CH2:5][CH2:4]1.[CH2:19]([C:21]1[C:25]([CH3:26])=[C:24]([CH3:27])[NH:23][C:22]=1[C:28](O)=[O:29])[CH3:20]>>[Cl:18][C:16]1[CH:15]=[C:11]([CH:10]=[C:9]([N:6]2[CH2:5][CH2:4][CH:3]([NH:2][C:28]([C:22]3[NH:23][C:24]([CH3:27])=[C:25]([CH3:26])[C:21]=3[CH2:19][CH3:20])=[O:29])[CH2:8][CH2:7]2)[N:17]=1)[C:12]([NH2:14])=[O:13]参加物
3
実験手順
Title compound was synthesized by an analogous method to Example 18 by coupling 2-(4-aminopiperidin-1-yl)-6-chloroisonicotinamide hydrochloride (Intermediate 70) with 3-ethyl-4,5-dimethyl-1H-pyrrole-2-carboxylic acid (commercially available).
出典と根拠
- ORDレコード
- ord-908005d20ada479abbba319168b680fa
- 出典データセット
- uspto-grants-2010_05