Ethanol → O-Ethyl (3-Chlorophenyl)-thiocarbamate
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([N:8]=[C:9]=[S:10])[CH:5]=[CH:6][CH:7]=1.N1C2C(=CC=CC=2)C=CC=1.[CH2:21]([OH:23])[CH3:22]>>[Cl:1][C:2]1[CH:3]=[C:4]([NH:8][C:9](=[S:10])[O:23][CH2:21][CH3:22])[CH:5]=[CH:6][CH:7]=1参加物
4
実験手順
A mixture of 45.5 gm (0.268 mol) of 3-chlorophenylisothiocyanate, 200 ml of anhydrous ethanol and 1 ml of quinoline was refluxed for 48 hours. Then, the reaction mixture was evaporated in an aspirator vacuum, the residue was taken up in ether, and the resulting solution was washed first with 5% hydrochloric acid and then thoroughly with water, dried, and evaporated again. After recrystallization from methanol/water, 49.5 gm (86% of theory) of colorless crystals with a melting point of 78°-79° C. were obtained.
後処理
- temperaturewas refluxed for 48 hours
- customThen, the reaction mixture was evaporated in an aspirator vacuum
- washthe resulting solution was washed first with 5% hydrochloric acid
- dry with materialthoroughly with water, dried
- customevaporated again
- customAfter recrystallization from methanol/water, 49.5 gm (86% of theory) of colorless crystals with a melting point of 78°-79° C.
- customwere obtained
出典と根拠
- ORDレコード
- ord-0314404d9a3246f4a990bc889874e10e
- 出典データセット
- uspto-grants-1982_10
- 特許番号
- US04353919
反応ノート
読み込み中…