1-[2-(4-Aminopiperidin-1-yl)-6-chloropyridin-4-yl]ethanone hydrochloride salt → N-[1-(4-Acetyl-6-chloro-2-pyridinyl)-4-piperidinyl]-3,4-dichloro-5-methyl-1H-pyrrole-2-carboxamide
反応式
Cl.[NH2:2][CH:3]1[CH2:8][CH2:7][N:6]([C:9]2[CH:14]=[C:13]([C:15](=[O:17])[CH3:16])[CH:12]=[C:11]([Cl:18])[N:10]=2)[CH2:5][CH2:4]1.[Cl:19][C:20]1[C:24]([Cl:25])=[C:23]([CH3:26])[NH:22][C:21]=1[C:27](NC1CCN(C2C=C(C3N=CON=3)C=C(Cl)N=2)CC1)=[O:28]>>[C:15]([C:13]1[CH:12]=[C:11]([Cl:18])[N:10]=[C:9]([N:6]2[CH2:7][CH2:8][CH:3]([NH:2][C:27]([C:21]3[NH:22][C:23]([CH3:26])=[C:24]([Cl:25])[C:20]=3[Cl:19])=[O:28])[CH2:4][CH2:5]2)[CH:14]=1)(=[O:17])[CH3:16]参加物
3
反応物 2
生成物 1
実験手順
The title compound was synthesized by an analogous method to Example 18 starting from 1-[2-(4-aminopiperidin-1-yl)-6-chloropyridin-4-yl]ethanone hydrochloride salt (Intermediate 197) and 3,4-dichloro-5-methyl-1H-pyrrole-2-carboxylic acid (Intermediate 3).
出典と根拠
- ORDレコード
- ord-f0ebdaee25f1406aba300136788e4f9a
- 出典データセット
- uspto-grants-2010_05
- 特許番号
- US07709503B2
反応ノート
読み込み中…