1-Methyl-2-imidazolecarboxaldehyde → 4-Bromo-5-methyl-N-{1-[(1-methyl-1H-imidazol-2-yl)methyl]piperidin-4-yl}-1H-pyrrole-2-carboxamide
反応式
Cl.[Br:2][C:3]1[CH:4]=[C:5]([C:9]([NH:11][CH:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)=[O:10])[NH:6][C:7]=1[CH3:8].[CH3:18][N:19]1[CH:23]=[CH:22][N:21]=[C:20]1[CH:24]=O>>[Br:2][C:3]1[CH:4]=[C:5]([C:9]([NH:11][CH:12]2[CH2:13][CH2:14][N:15]([CH2:24][C:20]3[N:19]([CH3:18])[CH:23]=[CH:22][N:21]=3)[CH2:16][CH2:17]2)=[O:10])[NH:6][C:7]=1[CH3:8]参加物
3
実験手順
Title compound was synthesized by an analogous method to Example 1 by coupling 4-bromo-5-methyl-N-piperidin-4-yl-1H-pyrrole-2-carboxamide hydrochloride (Intermediate 57) with 1-methyl-1H-imidazole-2-carbaldehyde (commercially available).
出典と根拠
- ORDレコード
- ord-c892e9141c0d4caab548f81fbffee484
- 出典データセット
- uspto-grants-2010_05
- 特許番号
- US07709503B2
反応ノート
読み込み中…