5-Bromo-1-methyl-1H-tetrazole → 4-Bromo-5-methyl-N-[1-(1-methyl-1H-tetrazol-5-yl)piperidin-4-yl]-1H-pyrrole-2-carboxamide

反応式

Cl.[Br:2][C:3]1[CH:4]=[C:5]([C:9]([NH:11][CH:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)=[O:10])[NH:6][C:7]=1[CH3:8].Br[C:19]1[N:23]([CH3:24])[N:22]=[N:21][N:20]=1>>[Br:2][C:3]1[CH:4]=[C:5]([C:9]([NH:11][CH:12]2[CH2:13][CH2:14][N:15]([C:19]3[N:23]([CH3:24])[N:22]=[N:21][N:20]=3)[CH2:16][CH2:17]2)=[O:10])[NH:6][C:7]=1[CH3:8]

参加物

反応物 2

HCID 127974465-Bromo-1-methyl-1H-tetrazole

HCID 68579819HCID 68579819、化合物2 回

生成物 1

HCID 685825664-Bromo-5-methyl-N-[1-(1-methyl-1H-tetrazol-5-yl)piperidin-4-yl]-1H-pyrrole-2-carboxamide

実験手順

Title compound was synthesized by an analogous method to Example 123 by coupling 4-bromo-5-methyl-N-piperidin-4-yl-1H-pyrrole-2-carboxamide hydrochloride (Intermediate 57) with 5-bromo-1-methyl-1H-tetrazole (Can. J. Chem. 1971, 49, 2139).

出典と根拠

ORDレコード: ord-61fc3059c4704b14a36ba378eea08da2
出典データセット: uspto-grants-2010_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07709503B2

反応ノート

読み込み中…