関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 18-Crown-6 | HCID 28557 | — |
| 反応物 | (S)-(+)-N,N-Dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine | HCID 9818212 | — |
| 反応物 | HCID 178418922 | HCID 178418922 | — |
| 溶媒 | Sulfolane | HCID 31347 | — |
| 生成物 | N,N-Dimethyl-3-((naphthalen-1-yl)oxy)-3-(thiophen-2-yl)propan-1-amine | HCID 11573192 | — |
反応手順
tBuOK (16.8 g), and 18-crown-6 (0.25 g) are added to a solution of (S)-N,N-dimethyl-3-(naphthyloxy)-3-(2-thienyl)propylamine (31 g) in sulfolane (100 ml), bubbled with a moderate stream of nitrogen, and the mixture is stirred and heated at 110° C. for 2 hours. After cooling down to lab temperature, the mixture is diluted with water (300 ml) and the racemic product is extracted with toluene. After evaporation, 25 g (81%) of RS)-N-methyl-3-(naphthyloxy)-3-(2-thienyl)propylamine is obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07709662B2 |
|---|
| 出典データセット | uspto-grants-2010_05 |
|---|
| ORD ID | ord-779cc6060383413d999ea845235342a3 |
|---|
| 出典メモ | uspto-grants-2010_05 |
|---|
