化工社化工社 化学情報印刷レポート · 研究参考用
4-Chlororesorcinol → 6-Chloro-7-hydroxy coumarin
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Chlororesorcinol | HCID 1731 | — |
| 反応物 | Ethyl alpha-benzylacetoacetate | HCID 246929 | — |
| 溶媒 | Sulfuric Acid | HCID 1118 | — |
| 生成物 | 6-Chloro-7-hydroxy coumarin | HCID 5393166 | 104.9% |
反応手順
4-Chlororesorcinol (26.25 g, 0.182 mol) and ethyl 2-benzylacetoacetate (40 g, 0.182 mol) are mixed in 70% H2SO4 (350 mL) at 0° C. The reaction mixture is stirred at room temperature for 72 hours and poured into ice water. The solid is filtered and washed with water. The crude product is recrystallized from ethanol/chloroform to afford 6-chloro-7-hydroxy coumarin intermediate (37.52 g, 68.7%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07709664B2 |
| 出典データセット | uspto-grants-2010_05 |
| ORD ID | ord-eeb1a068930844398b12dcfc3cf9e695 |
| 出典メモ | uspto-grants-2010_05 |