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Triethylamine → 3-[(5-Bromo-2-chloro-pyrimidin-4-yl)-propan-2-yl-amino]-N-methyl-propanamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 5-Bromo-2,4-dichloropyrimidine | HCID 289973 | — |
| 反応物 | 3-(Isopropylamino)-N-methylpropanamide | HCID 28307158 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 3-[(5-Bromo-2-chloro-pyrimidin-4-yl)-propan-2-yl-amino]-N-methyl-propanamide | HCID 86617567 | 78% |
反応手順
5-Bromo-2,4-dichloropyrimidine (1.83 g, 8.00 mmol), N-methyl-3-(propan-2-ylamino)propanamide (Intermediate 14, 1.16 g, 8.00 mmol) and Et3N (1.2 mL, 8.16 mmol) were combined in MeCN (50 mL) and shaken at ambient temperature for 3 days before the solvent was removed under reduced pressure. Purification by column chromatography (SiO2, eluent gradient 2-10% MeOH to DCM) to afford the title compound (2.08 g, 78%) as a gum.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07709471B2 |
| 出典データセット | uspto-grants-2010_05 |
| ORD ID | ord-2f21a35b607441999b26f4ec50a58342 |
| 出典メモ | uspto-grants-2010_05 |