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HRID 2234357作成日：2026年10月27日
2-fluoro-5-methoxy-N-(1-methylpiperidin-4-yl)-4-nitrobenzamide → 4-amino-2-fluoro-5-methoxy-N-(1-methylpiperidin-4-yl)benzamide
https://huagongshe.com/reaction/2234357
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2-fluoro-5-methoxy-N-(1-methylpiperidin-4-yl)-4-nitrobenzamide | HCID 67117746 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 4-amino-2-fluoro-5-methoxy-N-(1-methylpiperidin-4-yl)benzamide | HCID 66927285 | — |
反応手順
2-fluoro-5-methoxy-N-(1-methyl-4-piperidyl)-4-nitro-benzamide Intermediate 28; 1.3 g, 4.2 mmol) 10% Palladium on Carbon (100 mg) and Methanol (50 mL) were combined and stirred at 25° C. under Hydrogen at 1 bar pressure for 18 hours.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07709471B2 |
|---|
| 出典データセット | uspto-grants-2010_05 |
|---|
| ORD ID | ord-9ecb695237ea4969af047f347a4c79bc |
|---|
| 出典メモ | uspto-grants-2010_05 |
|---|
