Methylacrylamide → 3-(Sec-butylamino)-N-methylpropanamide

HRID 2234394ノート

反応式

HRID 2234394 の反応式
[CH3:1][NH:2][C:3](=[O:6])[CH:4]=[CH2:5].[CH:7]([NH2:11])([CH2:9][CH3:10])[CH3:8]>C(O)C>[CH3:8][CH:7]([NH:11][CH2:5][CH2:4][C:3]([NH:2][CH3:1])=[O:6])[CH2:9][CH3:10]

参加物

4

反応物 2

HCID 14471MethylacrylamideHCID 24874Sec-Butylamine

生成物 1

HCID 467360473-(Sec-butylamino)-N-methylpropanamide収率 68.2%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
140 °C

実験手順

A mixture of N-methylacrylamide (ABCR; 500 mg, 5.87 mmol), sec-butylamine (Aldrich; 530 mL, 5.22 mmol) and ethanol (4 mL) was heated in a microwave to 140° C. for 45 minutes and then at 150° C. for 30 minutes. The reaction mixture was cooled and poured onto an SCX-2 cartridge (5 g) and cartridge washed through with methanol (˜50 mL). Products were then eluted with 2M ammonia in methanol (˜50 mL) and evaporated to afford the title compound as a straw coloured oil (563 mg; 61%)

後処理

  1. temperatureThe reaction mixture was cooled
  2. additionpoured onto an SCX-2 cartridge (5 g) and cartridge
  3. washwashed through with methanol (˜50 mL)
  4. washProducts were then eluted with 2M ammonia in methanol (˜50 mL)
  5. customevaporated

出典と根拠

ORDレコード
ord-f376d88a2dd4488192f61fa516534766
出典データセット
uspto-grants-2010_05
特許番号
US07709471B2

反応ノート

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