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Triethylamine → 3-[(5-bromo-2-chloro-pyrimidin-4-yl)-(2-methoxyethyl)amino]-N-methyl-propanamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 5-Bromo-2,4-dichloropyrimidine | HCID 289973 | — |
| 反応物 | 3-[(2-Methoxyethyl)amino]-N-methylpropanamide | HCID 28307186 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 3-[(5-bromo-2-chloro-pyrimidin-4-yl)-(2-methoxyethyl)amino]-N-methyl-propanamide | HCID 86617579 | — |
反応手順
3-(2-methoxyethylamino)-N-methyl-propanamide (Intermediate 111; 608 mg, 3.79 mmol) 5-Bromo-2,4-dichloropyrimidine (Aldrich; 950 mg, 4.17 mmol), Triethylamine (555 μL, 3.98 mmol), and DCM (5 mL) were combined and stirred over the weekend at room temperature.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07709471B2 |
| 出典データセット | uspto-grants-2010_05 |
| ORD ID | ord-a5961b58485849628ccf1412df4a8bfc |
| 出典メモ | uspto-grants-2010_05 |