関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | 2-Methoxyethylamine | HCID 8018 | — |
| 反応物 | Methylacrylamide | HCID 14471 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 3-[(2-Methoxyethyl)amino]-N-methylpropanamide | HCID 28307186 | 65% |
反応手順
N-Methylacrylamide (ABCR; 500 mg, 5.87 mmol), 2-Methoxyethylamine (Aldrich; 441 mg, 5.87 mmol), and EtOH (2 mL) were combined and heated in a microwave at 140° C. for 40 minutes. The reaction mixture was cooled and added to a 5 g SCX-2 column pre-wet with MeOH (2 column volumes), flushed with MeOH (2 column volumes) then the product eluted with 2M ammonia in MeOH. Product containing fractions were evaporated in vacuo to give the title compound as a clear oil (608 mg, 65%)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07709471B2 |
|---|
| 出典データセット | uspto-grants-2010_05 |
|---|
| ORD ID | ord-542e4945d87a4bf388dd5870b467d054 |
|---|
| 出典メモ | uspto-grants-2010_05 |
|---|
