Cyclopentylamine → HCID 62326761、化合物

HRID 2234426ノート

反応式

HRID 2234426 の反応式
[CH2:1]([NH:3][C:4](=[O:7])[CH:5]=[CH2:6])[CH3:2].[CH:8]1([NH2:13])[CH2:12][CH2:11][CH2:10][CH2:9]1>CO>[CH:8]1([NH:13][CH2:6][CH2:5][C:4]([NH:3][CH2:1][CH3:2])=[O:7])[CH2:12][CH2:11][CH2:10][CH2:9]1

参加物

4

反応物 2

HCID 2906CyclopentylamineHCID 9793705N-Ethyl acrylamide

生成物 1

HCID 62326761HCID 62326761、化合物収率 80.3%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

N-ethylacrylamide (ABCR: 1.045 g, 10.50 mmol) and cyclopentylamine (Aldrich; 987 uL, 10.00 mmol) in methanol (10 mL) were combined in a microwave reaction vessel, which was sealed and irradiated to 140° C. for 30 minutes. The reaction mixture was allowed to cool and loaded directly onto a 50 g SCX-2 cartridge, washing with methanol (100 mL) and eluting the desired product with 7 N methanolic ammonia (100 mL). Concentration under reduced pressure of combined product containing fractions afforded the title compound as a brown oil (1.48 g, 80%)

後処理

  1. customwas sealed
  2. customirradiated to 140° C. for 30 minutes
  3. temperatureto cool
  4. washwashing with methanol (100 mL)
  5. washeluting the desired product with 7 N methanolic ammonia (100 mL)
  6. concentrationConcentration under reduced pressure of combined product
  7. additioncontaining fractions

出典と根拠

ORDレコード
ord-d94efcd05a5d4d2497713ea9e47862de
出典データセット
uspto-grants-2010_05
特許番号
US07709471B2

反応ノート

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