N,N-Dimethyl-1,4-cyclohexanediamine → 4-amino-5-chloro-N-(4-dimethylaminocyclohexyl)-2-fluoro-benzamide
反応式
[NH2:1][C:2]1[C:17]([Cl:18])=[CH:16][C:5]([C:6]([NH:8][CH:9]2[CH2:14][CH2:13]N(C)[CH2:11][CH2:10]2)=[O:7])=[C:4]([F:19])[CH:3]=1.NC1CC[CH:24]([N:27]([CH3:29])[CH3:28])CC1>>[NH2:1][C:2]1[C:17]([Cl:18])=[CH:16][C:5]([C:6]([NH:8][CH:9]2[CH2:10][CH2:11][CH:24]([N:27]([CH3:29])[CH3:28])[CH2:13][CH2:14]2)=[O:7])=[C:4]([F:19])[CH:3]=1参加物
3
実験手順
The title compound was prepared by an analogous method to the preparation of Intermediate 173, on a 2.64 mol scale, utilising 1-amino-4-dimethylaminocyclohexane (ABChem. Inc.; 472 mg, 3.31 mmol) after purification on a silica column (gradient (3-4% ammonia in methanol/DCM), as a pale brown foam (716 mg, 86%).
後処理
- customafter purification on a silica column (gradient (3-4% ammonia in methanol/DCM)
出典と根拠
- ORDレコード