Hydrochloric Acid → (3R)-1-Methyl-3-PyrrolidinaMine hydrochloride
反応式
[CH3:1][N:2]1[CH2:6][CH2:5][C@@H:4]([NH:7]C(=O)OC(C)(C)C)[CH2:3]1.[ClH:15]>O1CCOCC1>[ClH:15].[ClH:15].[CH3:1][N:2]1[CH2:6][CH2:5][C@@H:4]([NH2:7])[CH2:3]1参加物
4
実験手順
tert-butyl N-[(3R)-1-methylpyrrolidin-3-yl]carbamate (Intermediate 185; 1.18 g, 5.67 mmol) was dissolved in 1,4-dioxane (10 mL) and 4M HCl in dioxane (10 mL) added. The mixture was stirred at room temperature for 1 hour and then concentrated to yield the title compound as a white hygroscopic solid (810 mg, 100%).
後処理
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-aef1212eac7d477da2f0730538cbdad5
- 出典データセット
- uspto-grants-2010_05
- 特許番号
- US07709471B2
反応ノート
読み込み中…