1-Pyrrolidineethanamine → 4-amino-2,5-difluoro-N-(2-pyrrolidin-1-ylethyl)benzamide

反応式

[NH2:1][C:2]1[C:16]([F:17])=[CH:15][C:5]([C:6]([NH:8][C@@H:9]2[CH2:13][CH2:12][N:11]([CH3:14])[CH2:10]2)=[O:7])=[C:4]([F:18])[CH:3]=1.N1(CCN)CCC[CH2:20]1>>[NH2:1][C:2]1[C:16]([F:17])=[CH:15][C:5]([C:6]([NH:8][CH2:9][CH2:10][N:11]2[CH2:14][CH2:20][CH2:13][CH2:12]2)=[O:7])=[C:4]([F:18])[CH:3]=1

参加物

反応物 2

HCID 13441-Pyrrolidineethanamine

HCID 686824724-amino-2,5-difluoro-N-[(3R)-1-methylpyrrolidin-3-yl]benzamide

生成物 1

HCID 686828564-amino-2,5-difluoro-N-(2-pyrrolidin-1-ylethyl)benzamide

実験手順

The title compound was prepared by an analogous method to the preparation of Intermediate 229, on a 5.77 mmol scale utilising 2-pyrrolidin-1-ylethanamine (Aldrich; 725 mg, 6.35 mmol), as a beige solid (648 mg, 42%)

出典と根拠

ORDレコード: ord-cd1fe32b89bb4d00af61da4aed2c8ad0
出典データセット: uspto-grants-2010_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07709471B2

反応ノート

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