1-Ethylpiperidin-4-amine → 4-amino-N-(1-ethyl-4-piperidyl)-2,5-difluoro-benzamide

反応式

[NH2:1][C:2]1[C:16]([F:17])=[CH:15][C:5]([C:6](N[C@@H]2CCN(C)C2)=[O:7])=[C:4]([F:18])[CH:3]=1.[NH2:19][CH:20]1[CH2:25][CH2:24][N:23]([CH2:26][CH3:27])[CH2:22][CH2:21]1>>[NH2:1][C:2]1[C:16]([F:17])=[CH:15][C:5]([C:6]([NH:19][CH:20]2[CH2:25][CH2:24][N:23]([CH2:26][CH3:27])[CH2:22][CH2:21]2)=[O:7])=[C:4]([F:18])[CH:3]=1

参加物

反応物 2

HCID 37349901-Ethylpiperidin-4-amine

HCID 686824724-amino-2,5-difluoro-N-[(3R)-1-methylpyrrolidin-3-yl]benzamide

生成物 1

HCID 686848474-amino-N-(1-ethyl-4-piperidyl)-2,5-difluoro-benzamide

実験手順

The title compound was prepared by an analogous method to the preparation of Intermediate 229, on a 5.77 mmol scale utilising 4-amino-1-ethylpiperidine (Fluorochem; 815 mg, 6.35 mmol), as an orange solid (1.23 g, 75%)

出典と根拠

ORDレコード: ord-190563b857ff4a66a5fda50e9e900829
出典データセット: uspto-grants-2010_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07709471B2

反応ノート

読み込み中…