Bromine → 5-Bromo-3-fluoro-2-hydroxybenzoic acid

HRID 2234620ノート

反応式

HRID 2234620 の反応式
[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:4]([C:5]([OH:7])=[O:6])[C:3]=1[OH:11].[Br:12]Br>C(O)(=O)C.O>[Br:12][C:9]1[CH:10]=[C:2]([F:1])[C:3]([OH:11])=[C:4]([CH:8]=1)[C:5]([OH:7])=[O:6]

参加物

5

反応物 2

HCID 24408BromineHCID 2687243-Fluoro-2-hydroxybenzoic acid

生成物 1

HCID 117704165-Bromo-3-fluoro-2-hydroxybenzoic acid

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 962Water溶媒

実験手順

5.00 g (32 mmol) of 3-fluorosalicylic acid was suspended in 50 ml of glacial acetic acid. 2.2 ml of bromine were added and the mixture was stirred at ambient temperature for 48 h. The resulting suspension was diluted with 500 ml of water and the precipitate filtered off and dried by suction to afford 9.394 g of 5-bromo-3-fluoro-2-hydroxybenzoic acid as an ivory solid.

後処理

  1. filtrationthe precipitate filtered off
  2. customdried by suction

出典と根拠

ORDレコード
ord-663bbcfc74cf4592b87e6a84e91cbbbc
出典データセット
uspto-grants-2010_05
特許番号
US07709645B2

反応ノート

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