N-{5-[cis-3,5-Dimethyl-1-piperazinyl]-3-pyridinyl}-2,2,2-trifluoroacetamide → 5-[cis-3,5-Dimethyl-1-piperazinyl]-3-pyridinamine

反応式

[CH3:1][C@H:2]1[N:7](CC2C=CC=CC=2)[C@@H:6]([CH3:15])[CH2:5][N:4]([C:16]2[CH:17]=[C:18]([NH2:24])[C:19](OC)=[N:20][CH:21]=2)[CH2:3]1.C[C@H]1N[C@@H](C)CN(C2C=C(NC(=O)C(F)(F)F)C=NC=2)C1>>[CH3:1][C@H:2]1[NH:7][C@@H:6]([CH3:15])[CH2:5][N:4]([C:16]2[CH:17]=[C:18]([NH2:24])[CH:19]=[N:20][CH:21]=2)[CH2:3]1

参加物

反応物 2

HCID 58988131N-{5-[cis-3,5-Dimethyl-1-piperazinyl]-3-pyridinyl}-2,2,2-trifluoroacetamide

HCID 589881355-[cis-3,5-Dimethyl-4-(phenylmethyl)-1-piperazinyl]-2-(methyloxy)-3-pyridinamine

生成物 1

HCID 589881525-[cis-3,5-Dimethyl-1-piperazinyl]-3-pyridinamine

実験手順

The title compound was prepared in a manner similar to 5-[cis-3,5-dimethyl-4-(phenylmethyl)-1-piperazinyl]-2-(methyloxy)-3-pyridinamine (D29) using N-{5-[cis-3,5-dimethyl-1-piperazinyl]-3-pyridinyl}-2,2,2-trifluoroacetamide (D35) as the starting material.

出典と根拠

ORDレコード: ord-c1c66408b80d4188af524663a761addf
出典データセット: uspto-grants-2010_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07713978B2

反応ノート

読み込み中…

参加物