Ethanol → HCID 68439912、化合物

HRID 2235041ノート

反応式

HRID 2235041 の反応式
[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[C:17]3[C:12](=[CH:13][C:14]([F:27])=[C:15]([N:19]4[CH2:22][CH:21]([NH:23][CH:24]([CH3:26])[CH3:25])[CH2:20]4)[C:16]=3[Br:18])[C:11](=[O:28])[C:10]([C:29]([OH:31])=[O:30])=[CH:9]2)[C:5]([F:32])=[CH:4][C:3]=1[F:33].[C:34]([OH:41])(=[O:40])/[CH:35]=[CH:36]\[C:37]([OH:39])=[O:38].C(O)C>O>[C:34]([OH:41])(=[O:40])/[CH:35]=[CH:36]\[C:37]([OH:39])=[O:38].[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[C:17]3[C:12](=[CH:13][C:14]([F:27])=[C:15]([N:19]4[CH2:20][CH:21]([NH:23][CH:24]([CH3:26])[CH3:25])[CH2:22]4)[C:16]=3[Br:18])[C:11](=[O:28])[C:10]([C:29]([OH:31])=[O:30])=[CH:9]2)[C:5]([F:32])=[CH:4][C:3]=1[F:33]

参加物

5

反応物 3

HCID 702EthanolHCID 444266Maleic AcidHCID 68439913HCID 68439913、化合物

生成物 1

HCID 68439912HCID 68439912、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
80 °C

実験手順

1-(6-Amino-3,5-difluoropyridin-2-yl)-8-bromo-6-fluoro-7-(3-isopropylaminoazetidin-1-yl)-4-oxo-1,4-dihydroquinolin-3-carboxylic acid (132 mg) and maleic acid (58 mg) were added to ethanol (3 mL), and the mixture was heated at 80° C. Water was gradually added to the mixture until the compounds were completely dissolved. After the solution had been left to cool, the formed solid was collected through filtration, to thereby yield 102 mg of the title compound.

後処理

  1. dissolutionwere completely dissolved
  2. waitAfter the solution had been left
  3. temperatureto cool
  4. filtrationthe formed solid was collected through filtration

出典と根拠

ORDレコード
ord-31725629c7b4403c8215b20a560bee53
出典データセット
uspto-grants-2010_05
特許番号
US07713997B2

反応ノート

読み込み中…