2-(Bromomethyl)-1,3-dichloro-5-methoxybenzene → 3-(2,6-Dichloro-4-methoxybenzyl)-1-(cis-2-methylcyclohexyl)pyrrolidin-2-one
反応式
[CH3:1][C@H:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C@H:3]1[N:8]1[CH2:12][CH2:11][CH2:10][C:9]1=[O:13].Br[CH2:15][C:16]1[C:21]([Cl:22])=[CH:20][C:19]([O:23][CH3:24])=[CH:18][C:17]=1[Cl:25]>>[Cl:22][C:21]1[CH:20]=[C:19]([O:23][CH3:24])[CH:18]=[C:17]([Cl:25])[C:16]=1[CH2:15][CH:10]1[CH2:11][CH2:12][N:8]([C@@H:3]2[CH2:4][CH2:5][CH2:6][CH2:7][C@@H:2]2[CH3:1])[C:9]1=[O:13]参加物
3
実験手順
Using the procedure to synthesize Example 1 and using reagents 1-(cis-2-methyl-cyclohexyl)-pyrrolidin-2-one (Preparation 32) (1.0 g, 5.52 mmol) and 2-(bromomethyl)-1,3-dichloro-5-methoxybenzene (1.24 g, 5.52 mmol) gives 1.29 g (63%) 3-(2,6-Dichloro-4-methoxybenzyl)-1-(cis-2-methylcyclohexyl)pyrrolidin-2-one as a white solid.
後処理
- customto synthesize Example 1