(4-Chloro-3-(trifluoromethoxy)phenyl)methanol → 4-Chloro-3-(trifluoromethoxy)benzyl bromide

反応式

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8]O)=[CH:4][C:3]=1[O:10][C:11]([F:14])([F:13])[F:12].[Br:15]C1C=C(CBr)C=CC=1OC(F)(F)F>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][Br:15])=[CH:4][C:3]=1[O:10][C:11]([F:14])([F:13])[F:12]

参加物

反応物 2

HCID 17750696(4-Chloro-3-(trifluoromethoxy)phenyl)methanol

HCID 593006712-Bromo-4-(bromomethyl)-1-(trifluoromethoxy)benzene

生成物 1

HCID 177506974-Chloro-3-(trifluoromethoxy)benzyl bromide

実験手順

Compound 35.2 was synthesized from (4-chloro-3-(trifluoromethoxy)phenyl)-methanol using the procedure described for the preparation of 19.2. 1H NMR (500 MHz, DMSO-d6) δ 7.74 (1H, d, J=2.0 Hz), 7.38-7.53 (2H, m), 4.53 (2H, d, J=5.6 Hz)

出典と根拠

ORDレコード: ord-e1e907ee3a054d8bb62c7f07b15f2745
出典データセット: uspto-grants-2010_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07714008B2

反応ノート

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