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Triethylamine → 2-(Chloromethyl)-5-(4-(trifluoromethyl)phenyl)thiophene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | 2-Thiophenemethanol, 5-[4-(trifluoromethyl)phenyl]- | HCID 21986352 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2-(Chloromethyl)-5-(4-(trifluoromethyl)phenyl)thiophene | HCID 57594979 | — |
反応手順
To a solution of 61.3 (45 mg, 0.18 mmol) in DCM (0.9 mL) were added triethylamine (24 μL, 0.18 mmol) and thionyl chloride (19 μL, 0.26 mmol) at room temperature. The mixture was stirred overnight and concentrated to afford 61.4. The crude product was used without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07714008B2 |
| 出典データセット | uspto-grants-2010_05 |
| ORD ID | ord-107a5558379b4409853e9c706a2f125f |
| 出典メモ | uspto-grants-2010_05 |