5-chloro-2-(3,4,5-trifluorophenyl)pentanoic acid N'-{(E)-3-[3-fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl]acryloyl}hydrazide → 2-[4-chloro-1-(3,4,5-trifluorophenyl)butyl]-5-{(E)-2-[3-fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl]vinyl}-[1,3,4]oxadiazole
反応式
[F:1][C:2]1[CH:3]=[C:4](/[CH:14]=[CH:15]/[C:16]([NH:18][NH:19][C:20](=O)[CH:21]([C:26]2[CH:31]=[C:30]([F:32])[C:29]([F:33])=[C:28]([F:34])[CH:27]=2)[CH2:22][CH2:23][CH2:24][Cl:25])=[O:17])[CH:5]=[CH:6][C:7]=1[N:8]1[CH:12]=[C:11]([CH3:13])[N:10]=[CH:9]1>P(Cl)(Cl)(Cl)=O>[Cl:25][CH2:24][CH2:23][CH2:22][CH:21]([C:20]1[O:17][C:16](/[CH:15]=[CH:14]/[C:4]2[CH:5]=[CH:6][C:7]([N:8]3[CH:12]=[C:11]([CH3:13])[N:10]=[CH:9]3)=[C:2]([F:1])[CH:3]=2)=[N:18][N:19]=1)[C:26]1[CH:31]=[C:30]([F:32])[C:29]([F:33])=[C:28]([F:34])[CH:27]=1参加物
3
反応物 1
生成物 1
試薬・触媒・溶媒 1
実験手順
A solution of 5-chloro-2-(3,4,5-trifluorophenyl)pentanoic acid N′-{(E)-3-[3-fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl]acryloyl}hydrazide (103 mg) in phosphorus oxychloride (2 mL) was stirred at 120° C. for 3.5 hours. The reaction solution was left to cool to room temperature and then concentrated under reduced pressure to obtain 99 mg of the title compound. The property value of the compound is as follows.