tert-butyl N'-[5-chloro-2-(4-fluorophenyl)-2-methoxypentanoyl]hydrazinecarboxylate → 5-Chloro-2-(4-fluorophenyl)-2-methoxyvaleric acid hydrazide monohydrochloride

HRID 2235744ノート

反応式

HRID 2235744 の反応式
[Cl:1][CH2:2][CH2:3][CH2:4][C:5]([C:19]1[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=1)([O:17][CH3:18])[C:6]([NH:8][NH:9]C(OC(C)(C)C)=O)=[O:7]>Cl.O1CCOCC1>[ClH:1].[Cl:1][CH2:2][CH2:3][CH2:4][C:5]([C:19]1[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=1)([O:17][CH3:18])[C:6]([NH:8][NH2:9])=[O:7]

参加物

4

反応物 1

HCID 67067169tert-butyl N'-[5-chloro-2-(4-fluorophenyl)-2-methoxypentanoyl]hydrazinecarboxylate

生成物 1

HCID 670671765-Chloro-2-(4-fluorophenyl)-2-methoxyvaleric acid hydrazide monohydrochloride収率 216.8%

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 312751,4-Dioxane溶媒

実験手順

tert-Butyl N′-[5-chloro-2-(4-fluorophenyl)-2-methoxypentanoyl]hydrazinecarboxylate (90 mg) was dissolved in a solution of 4 N hydrogen chloride in dioxane (1 mL), and the reaction solution was stirred at room temperature for 70 minutes. The reaction solution was concentrated under reduced pressure to obtain 81 mg of the title compound. The property value of the compound is as follows.

後処理

  1. concentrationThe reaction solution was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-676b75cb52ea411e938b4d0dbb5974ae
出典データセット
uspto-grants-2010_05
特許番号
US07713993B2

反応ノート

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