化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → Diflunisal
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Methyl 2',4'-difluoro-4-hydroxy-[1,1'-biphenyl]-3-carboxylate | HCID 491921 | — |
| 生成物 | Diflunisal | HCID 3059 | — |
反応手順
The product of Step A above is suspended in 8.0 ml. of aqueous sodium hydroxide (5%) and refluxed for 30 minutes. The mixture is acidified with aqueous hydrochloric acid and extracted three times with 15.0 ml. of toluene. The combined toluene extracts are concentrated to afford 2.3 mmole of 5-(2,4-difluorophenyl)salicylic acid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04355174 |
| 出典データセット | uspto-grants-1982_10 |
| ORD ID | ord-1345b11bb9a5477eab8447663fa01bdd |
| 出典メモ | uspto-grants-1982_10 |