Phenylhydrazine hydrochloride → 2,3,4,5-Tetrahydro-1H-pyrido[4,3-b]indole hydrochloride
反応式
[ClH:1].O.[NH:3]1[CH2:8][CH2:7][C:6](=O)[CH2:5][CH2:4]1.Cl.[C:11]1([NH:17]N)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>C(O)C>[ClH:1].[CH2:4]1[C:5]2[C:16]3[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=3[NH:17][C:6]=2[CH2:7][CH2:8][NH:3]1参加物
4
実験手順
4-Piperidone monohydrate hydrochloride (10 g, 65.1 mmol) and phenylhydrazine hydrochloride (9.4 g, 65.1 mmol) are suspended in ethanol (200 ml) and stirred at reflux overnight. The resulting solid is filtered off and washed with diethyl ether to afford pure sub-title compound (11.9 g) in 88% yield. tR (LC-2) 0.89; ESI-MS (positive ion): m/z 173.34 [M+H]+ (calcd 172.23 for C11H12N2).
後処理
- temperatureat reflux overnight
- filtrationThe resulting solid is filtered off
- washwashed with diethyl ether
出典と根拠
- ORDレコード
- ord-96e7a1b6446b460c818ddf17c8a17d1e
- 出典データセット
- uspto-grants-2010_05
- 特許番号
- US07714132B2
反応ノート
読み込み中…