Piperonylamine → 8-Methoxy-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole
反応式
Cl.O.[NH:3]1[CH2:8][CH2:7][C:6](=O)[CH2:5][CH2:4]1.Cl.[CH3:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([NH:19]N)=[CH:15][CH:14]=1>C(O)C>[CH3:11][O:12][C:13]1[CH:18]=[CH:17][C:16]2[NH:19][C:6]3[CH2:5][CH2:4][NH:3][CH2:8][C:7]=3[C:15]=2[CH:14]=1参加物
4
実験手順
A suspension of 4-piperidone monohydrate hydrochloride (1.0 g, 6.5 mmol) and 4-methoxyphenylhydrazine hydrochloride (1.14 g, 6.5 mmol) in ethanol (17 ml) is kept stirring at reflux overnight. The resulting solid is filtered off and washed with diethyl ether to afford crude sub-title compound, which is used without further purification: tR (LC-1) 0.38; ESI-MS (positive ion): m/z 203.19 [M+H]+ (calcd 202.25 for C12H14N2O).
後処理
- temperatureat reflux overnight
- filtrationThe resulting solid is filtered off
- washwashed with diethyl ether
出典と根拠
- ORDレコード
- ord-20d12c8a9c654fc2ac752bec5935fac4
- 出典データセット
- uspto-grants-2010_05
- 特許番号
- US07714132B2
反応ノート
読み込み中…