1-Methyl-3-phenyl-1H-pyrazole-5-carboxylic acid → HCID 59301315、化合物
反応式
[CH3:1][N:2]1[C:6]([C:7]([OH:9])=O)=[CH:5][C:4]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[N:3]1.[CH3:16][O:17][CH2:18][CH2:19][N:20]([CH3:28])[C:21]1[CH:26]=[CH:25][C:24]([NH2:27])=[CH:23][N:22]=1>>[CH3:16][O:17][CH2:18][CH2:19][N:20]([CH3:28])[C:21]1[N:22]=[CH:23][C:24]([NH:27][C:7]([C:6]2[N:2]([CH3:1])[N:3]=[C:4]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)[CH:5]=2)=[O:9])=[CH:25][CH:26]=1参加物
3
実験手順
With a procedure similar to example 16 above, 2-methyl-5-phenyl-2H-pyrazole-3-carboxylic acid {6-[(2-methoxy-ethyl)-methyl-amino]-pyridin-3-yl}-amide was prepared from 2-methyl-5-phenyl-2H-pyrazole-3-carboxylic acid (made by hydrolysis of the corresponding commercially available ethyl ester) and N2-(2-methoxy-ethyl)-N2-methyl-pyridine-2,5-diamine. LCMS calcd for C20H23N5O2 (m/e) 365, obsd 366 (M+H). The NMR spectrum obtained on the sample is compatible with its structure.
後処理
- customThe NMR spectrum obtained on the sample