2-Phenyl-5-(trifluoromethyl)-oxazole-4-carboxylic acid → HCID 59301384、化合物
反応式
[C:1]1([C:7]2[O:8][C:9]([C:15]([F:18])([F:17])[F:16])=[C:10]([C:12]([OH:14])=O)[N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:19][C:20]1[CH:21]=[CH:22][C:23]([N:26]2[CH2:31][CH2:30][CH:29]([OH:32])[CH2:28][CH2:27]2)=[N:24][CH:25]=1>>[OH:32][CH:29]1[CH2:30][CH2:31][N:26]([C:23]2[CH:22]=[CH:21][C:20]([NH:19][C:12]([C:10]3[N:11]=[C:7]([C:1]4[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=4)[O:8][C:9]=3[C:15]([F:18])([F:17])[F:16])=[O:14])=[CH:25][N:24]=2)[CH2:27][CH2:28]1参加物
3
実験手順
With a procedure similar to example 43 above, 2-phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid (4-hydroxy-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-5′-yl)-amide was prepared from 2-phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid and 5′-amino-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-ol. LCMS calcd for C21H19F3N4O3 (m/e) 432, obsd 433 (M+H).
出典と根拠
- ORDレコード
- ord-59cc45fecb314f49a2c172a9b8366713
- 出典データセット
- uspto-grants-2010_05
- 特許番号
- US07714126B2