2-Furan-3-yl-5-hydroxy-benzonitrile → 3-Aminomethyl-4-furan-3-yl-phenol

HRID 2236427ノート

反応式

HRID 2236427 の反応式
[O:1]1[CH:5]=[CH:4][C:3]([C:6]2[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][C:7]=2[C:8]#[N:9])=[CH:2]1>CCO.[Ni]>[NH2:9][CH2:8][C:7]1[CH:10]=[C:11]([OH:14])[CH:12]=[CH:13][C:6]=1[C:3]1[CH:4]=[CH:5][O:1][CH:2]=1

参加物

4

反応物 1

HCID 593001112-Furan-3-yl-5-hydroxy-benzonitrile

生成物 1

HCID 593002373-Aminomethyl-4-furan-3-yl-phenol収率 72%

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 702Ethanol溶媒

実験手順

The 2-Furan-3-yl-5-hydroxy-benzonitrile obtained above is dissolved in EtOH and to which Raney Ni (1 g of suspension in water) is added. The mixture is then subjected to hydrogenation under H2 (50 psi) for 24 hours. After which Raney Ni is filtered off from celite and EtOH is removed to provide the title compound (40 mg, 72% for two steps). MS (ESI): 190 (M+1)+1, 173 (M+1-NH3)+1.

後処理

  1. additionis added
  2. filtrationAfter which Raney Ni is filtered off from celite and EtOH
  3. customis removed

出典と根拠

ORDレコード
ord-5d8dbbbb82024049b6a36d5dd8dfd73f
出典データセット
uspto-grants-2010_05
特許番号
US07713994B2

反応ノート

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