関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Cesium carbonate | HCID 10796 | — |
| 反応物 | 4-Fluorophenylboronic acid | HCID 285645 | — |
| 反応物 | Methyl 4-iodo-3-methoxybenzoate | HCID 11243290 | — |
| 触媒 | HCID 178418397 | HCID 178418397 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 4'-Fluoro-2-methoxy-biphenyl-4-carboxylic acid methyl ester | HCID 59299900 | 92.2% |
反応手順
4-Iodo-3-methoxy-benzoic acid methyl ester (292 mg, 1 mmol) and para-fluorophenylboronic acid (160 mg, 1.14 mmol) and Pd(PPh3)4 (80 mg, 0.069 mmol) and Cs2CO3 (600 mg, 1.84 mmol) is mixed in N,N-dimethylformamide (10 mL) and degassed and then heated at 100° C. for 4 hours. After which, the mixture is allowed to cool to room temperature and an aqueous work up is performed and the residue purified to afford the desired product (240 mg, 92%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07713994B2 |
|---|
| 出典データセット | uspto-grants-2010_05 |
|---|
| ORD ID | ord-48da92eea70c4d6aaf980512b629b03a |
|---|
| 出典メモ | uspto-grants-2010_05 |
|---|
