3-Hydroxy-4-phenylbenzylamine → 4-Aminomethyl-4'-fluoro-biphenyl-2-ol

HRID 2236469ノート

反応式

HRID 2236469 の反応式
NCC1C=C(O)C(C2C=CC=CC=2)=CC=1.[N:16]([CH2:19][C:20]1[CH:21]=[C:22]([OH:33])[C:23]([C:26]2[CH:31]=[CH:30][C:29]([F:32])=[CH:28][CH:27]=2)=[CH:24][CH:25]=1)=[N+]=[N-]>>[NH2:16][CH2:19][C:20]1[CH:21]=[C:22]([OH:33])[C:23]([C:26]2[CH:31]=[CH:30][C:29]([F:32])=[CH:28][CH:27]=2)=[CH:24][CH:25]=1

参加物

3

反応物 2

HCID 231438563-Hydroxy-4-phenylbenzylamineHCID 593000244-Azidomethyl-4'-fluoro-biphenyl-2-ol

生成物 1

HCID 592999224-Aminomethyl-4'-fluoro-biphenyl-2-ol収率 54%

実験手順

Following the same procedure for the preparation of 4-Aminomethyl-biphenyl-2-ol, the title compound is prepared from 4-Azidomethyl-4′-fluoro-biphenyl-2-ol (crude material from the previous step) in 54% yield (over 4 steps). MS (ESI): 218 (M+1)+1.

出典と根拠

ORDレコード
ord-479d3efa403941b8aa0cda325af43117
出典データセット
uspto-grants-2010_05
特許番号
US07713994B2

反応ノート

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