Boron tribromide → HCID 59300378、化合物
反応式
[Br:1][C:2]1[C:9]([O:10]C)=[CH:8][C:5]([CH:6]=[O:7])=[C:4]([F:12])[CH:3]=1.B(Br)(Br)Br>C(Cl)Cl>[Br:1][C:2]1[C:9]([OH:10])=[CH:8][C:5]([CH:6]=[O:7])=[C:4]([F:12])[CH:3]=1参加物
4
反応条件
- 温度
- -78 °C
実験手順
4-Bromo-2-fluoro-5-methoxy-benzaldehyde (100 mg, 0.43 mmol) is dissolved in CH2Cl2 and cooled to −78° C. and then BBr3 (2 mL, 1 M solution in CH2Cl2, 2 mmol) is added. The resulting mixture is allowed to stir at room temperature until no starting material is left. The reaction is quenched and the product is isolated after chromatography (60 mg, 57%). MS (ESI): 216.9 (M−1)−1.
後処理
- waitis left
- customThe reaction is quenched
- customthe product is isolated after chromatography (60 mg, 57%)
出典と根拠
- ORDレコード
- ord-b17f48562cb442448910c7423e45e13c
- 出典データセット
- uspto-grants-2010_05
- 特許番号
- US07713994B2
反応ノート
読み込み中…