Propionic anhydride → (E)-3-(2,3-dichloro-styryl)-5-ethyl-1,2,4-oxadiazole

HRID 22365

反応式

HRID 22365 の反応式
[Cl:1][C:2]1[C:13]([Cl:14])=[CH:12][CH:11]=[CH:10][C:3]=1/[CH:4]=[CH:5]/[C:6](=[N:8][OH:9])[NH2:7].[C:15](OC(=O)CC)(=O)[CH2:16][CH3:17]>>[Cl:1][C:2]1[C:13]([Cl:14])=[CH:12][CH:11]=[CH:10][C:3]=1/[CH:4]=[CH:5]/[C:6]1[N:7]=[C:15]([CH2:16][CH3:17])[O:9][N:8]=1

参加物

3

反応物 2

HCID 31263Propionic anhydrideHCID 86748752(E)-2,3-dichlorocinnamamide oxime

生成物 1

HCID 21751478(E)-3-(2,3-dichloro-styryl)-5-ethyl-1,2,4-oxadiazole収率 58.2%

実験手順

7.0 g (0.03 tool) of (E)-2,3-dichlorocinnamamide oxime are initially introduced into 7 ml of propionic anhydride and the mixture is then stirred at reflux temperature for 2 hours. Subsequently, the whole batch is concentrated in vacuo, and the residue is stirred with sodium carbonate solution and extracted with methylene chloride. The organic phase is dried over sodium sulphate and the solvent is distilled off. 4.7 g (58.2% of theory) of (E) -3- (2,3 -dichloro-styryl) -5-ethyl-1,2,4-oxadiazole are obtained.

後処理

  1. temperatureat reflux temperature for 2 hours
  2. concentrationSubsequently, the whole batch is concentrated in vacuo
  3. stirringthe residue is stirred with sodium carbonate solution
  4. extractionextracted with methylene chloride
  5. dry with materialThe organic phase is dried over sodium sulphate
  6. distillationthe solvent is distilled off

出典と根拠

ORDレコード
ord-a5c6763878c1464587c4cf8a8d4436e0
出典データセット
uspto-grants-1995_06
特許番号
US05428049

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