Dimethylamine → [1-(2-Fluoro-4-nitro-phenyl)-pyrrolidin-2-ylmethyl]-dimethyl-amine

HRID 2236511ノート

反応式

HRID 2236511 の反応式
[F:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:4][C:3]=1[N:11]1[CH2:15][CH2:14][CH2:13][CH:12]1[CH:16]=O.[CH3:18][NH:19][CH3:20].[BH-](OC(C)=O)(OC(C)=O)OC(C)=O.[Na+]>C(Cl)Cl>[F:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:4][C:3]=1[N:11]1[CH2:15][CH2:14][CH2:13][CH:12]1[CH2:16][N:19]([CH3:20])[CH3:18]

参加物

5

反応物 3

HCID 674DimethylamineHCID 5049666Sodium triacetoxyborohydrideHCID 593003601-(2-Fluoro-4-nitro-phenyl)-pyrrolidine-2-carbaldehyde

生成物 1

HCID 59300313[1-(2-Fluoro-4-nitro-phenyl)-pyrrolidin-2-ylmethyl]-dimethyl-amine収率 69%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

1-(2-Fluoro-4-nitro-phenyl)-pyrrolidine-2-carbaldehyde (100 mg, 0.42 mmol) and dimethylamine (large excess) is stirred at room temperature in CH2Cl2 for 5 min and NaBH(OAc)3 (120 mg, 0.57 mmol) is added. The reaction is stopped after 30 min as TLC suggested complete conversion and the desired product (77 mg, 69%) is isolated after chromatography.

出典と根拠

ORDレコード
ord-b2bba44e5e5b409faf366d48089cc8eb
出典データセット
uspto-grants-2010_05
特許番号
US07713994B2

反応ノート

読み込み中…