Dimethylformamide → HCID 178487208、化合物

HRID 2236611ノート

反応式

HRID 2236611 の反応式
Cl.[NH2:2][CH2:3][C:4]1[CH:5]=[CH:6][C:7]([O:11][CH3:12])=[C:8]([OH:10])[CH:9]=1.CN(C)C=O.C(N(CC)CC)C.[CH3:25][O:26][C:27]1[CH:28]=[C:29]2[C:34](=[CH:35][CH:36]=1)[C:33](=[O:37])[NH:32][C:31](=[O:38])/[C:30]/2=[CH:39]/OC>CCOCC>[OH:10][C:8]1[CH:9]=[C:4]([CH:5]=[CH:6][C:7]=1[O:11][CH3:12])[CH2:3][NH:2][CH:39]=[C:30]1[C:29]2[C:34](=[CH:35][CH:36]=[C:27]([O:26][CH3:25])[CH:28]=2)[C:33](=[O:37])[NH:32][C:31]1=[O:38]

参加物

6

反応物 4

HCID 6228DimethylformamideHCID 8471TriethylamineHCID 162176463-Hydroxy-4-methoxybenzylamine hydrochlorideHCID 59299827(4E)-6-methoxy-4-methoxymethylene-4H-isoquinoline-1,3-dione

生成物 1

HCID 178487208HCID 178487208、化合物

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

A mixture of 5-aminomethyl-2-methoxy-phenol hydrochloride (145 mg, 0.50 mmole), 4 mL of N,N-dimethylformamide and triethylamine (75 □L, 0.54 mmole) is stirred for 15 minutes. Then (4E)-6-methoxy-4-methoxymethylene-4H-isoquinoline-1,3-dione (117 mg, 0.50 mmole) is added and the reaction mixture stirred for one hour. The reaction mixture is diluted with ether, filtered washed with water, washed with ether and dried to give an light beige solid, 161 mg, (91%), mp 240-2° C. dec; MS (ESI): m/z 355.2 (M−H).

後処理

  1. stirringthe reaction mixture stirred for one hour
  2. filtrationfiltered
  3. washwashed with water
  4. washwashed with ether
  5. customdried
  6. customto give an light beige solid, 161 mg, (91%), mp 240-2° C. dec

出典と根拠

ORDレコード
ord-449c492213ae44eaa57f91c39f9fc1d7
出典データセット
uspto-grants-2010_05
特許番号
US07713994B2

反応ノート

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