3-Hydroxy-4-phenylbenzylamine → HCID 178518360、化合物

HRID 2236862ノート

反応式

HRID 2236862 の反応式
[NH2:1][CH2:2][C:3]1[CH:4]=[C:5]([OH:15])[C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:7][CH:8]=1.[I:16][C:17]1[CH:18]=[C:19]2[C:24](=[CH:25][CH:26]=1)[C:23](=[O:27])[NH:22][C:21](=[O:28])[C:20]2=[CH:29]OC>CN(C)C=O>[OH:15][C:5]1[CH:4]=[C:3]([CH2:2][NH:1][CH:29]=[C:20]2[C:19]3[C:24](=[CH:25][CH:26]=[C:17]([I:16])[CH:18]=3)[C:23](=[O:27])[NH:22][C:21]2=[O:28])[CH:8]=[CH:7][C:6]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

参加物

4

反応物 2

HCID 231438563-Hydroxy-4-phenylbenzylamineHCID 686910194-methoxymethylene-6-iodo-4H-isoquinoline-1,3-dione

生成物 1

HCID 178518360HCID 178518360、化合物収率 89.5%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

4-Aminomethyl-biphenyl-2-ol (80 mg, 0.4 mmol) and 6-iodo-4-methoxymethylene-4H-isoquinoline-1,3-dione (110 mg, 0.34 mmol) is stirred in N,N-dimethylformamide (5 mL). After which N,N-dimethylformamide is removed under vacuum and the residue is triturated with MeOH. The precipitate thus formed is collected and washed with MeOH and dried to provide the title compound (151 mg, 89%). MS (ESI): 495.1 (M−1)−1.

後処理

  1. customAfter which N,N-dimethylformamide is removed under vacuum
  2. customthe residue is triturated with MeOH
  3. customThe precipitate thus formed
  4. customis collected
  5. washwashed with MeOH
  6. customdried

出典と根拠

ORDレコード
ord-dae6d350212d43ed91dae3eabd769649
出典データセット
uspto-grants-2010_05
特許番号
US07713994B2

反応ノート

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