(4E)-6-t-butyl-4-(methoxymethylene)isoquinoline-1,3(2H,4H)-dione → HCID 178458786、化合物

HRID 2236895ノート

反応式

HRID 2236895 の反応式
[C:1]([C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[C:11](=[O:15])[NH:10][C:9](=[O:16])/[C:8]/2=[CH:17]/OC)([CH3:4])([CH3:3])[CH3:2].[NH2:20][CH2:21][C:22]1[CH:27]=[C:26]([OH:28])[C:25]([O:29][CH2:30][CH2:31][CH3:32])=[CH:24][N:23]=1>CN(C)C=O>[C:1]([C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[C:11](=[O:15])[NH:10][C:9](=[O:16])[C:8]2=[CH:17][NH:20][CH2:21][C:22]1[CH:27]=[C:26]([OH:28])[C:25]([O:29][CH2:30][CH2:31][CH3:32])=[CH:24][N:23]=1)([CH3:4])([CH3:3])[CH3:2]

参加物

4

反応物 2

HCID 42625173(4E)-6-t-butyl-4-(methoxymethylene)isoquinoline-1,3(2H,4H)-dioneHCID 178458783HCID 178458783、化合物

生成物 1

HCID 178458786HCID 178458786、化合物収率 66%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

An amount of 50.0 mg (0.193 mmol) of (4E)-6-tert-butyl-4-(methoxymethylene)isoquinoline-1,3(2H,4H)-dione, is dissolved in N,N-dimethylformamide (3 mL), followed by the addition of 35 mg (0.193 mmol) of 2-aminomethyl-5-propoxy-pyridin-4-ol. All solids dissolved and after the mixture is stirred at room temperature for 2 hours, the solution is evaporated to dryness in vacuo, treated with acetonitrile, filtered and washed several times with fresh acetonitrile and dried to give 52 mg of the title compound as a light pink solid (66% yield); mp 162-178° C. dec, MS data ES(+) 410.4 m/e.

後処理

  1. dissolutionAll solids dissolved
  2. customthe solution is evaporated to dryness in vacuo
  3. additiontreated with acetonitrile
  4. filtrationfiltered
  5. washwashed several times with fresh acetonitrile
  6. customdried

出典と根拠

ORDレコード
ord-c286da46e3254da3af024ab6b5daa07c
出典データセット
uspto-grants-2010_05
特許番号
US07713994B2

反応ノート

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