Hydrazine → N-(4-aminobenzyl)ethanesulfonamide

HRID 2236928ノート

反応式

HRID 2236928 の反応式
[N+:1]([C:4]1[CH:16]=[CH:15][C:7]([CH2:8][NH:9][S:10]([CH2:13][CH3:14])(=[O:12])=[O:11])=[CH:6][CH:5]=1)([O-])=O.NN>[Ni].CO>[NH2:1][C:4]1[CH:16]=[CH:15][C:7]([CH2:8][NH:9][S:10]([CH2:13][CH3:14])(=[O:12])=[O:11])=[CH:6][CH:5]=1

参加物

5

反応物 2

HCID 9321HydrazineHCID 47372696N-(4-nitrobenzyl)ethanesulfonamide

生成物 1

HCID 39243426N-(4-aminobenzyl)ethanesulfonamide

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 887Methanol溶媒

実験手順

To the residue of the product from step 1 (0.25 mmol) is added methanol (350 μL), hydrazine (33 μL), and Raney-Nickel (10 mg). The reaction mixture is shaken at room temperature for 16 hours, then filtered and the solution concentrated to yield ethanesulfonic acid 4-amino-benzylamide, which is used as such for the subsequent reaction.

後処理

  1. filtrationfiltered
  2. concentrationthe solution concentrated

出典と根拠

ORDレコード
ord-56f987b31f4c49e5bdcb88db96800530
出典データセット
uspto-grants-2010_05
特許番号
US07713994B2

反応ノート

読み込み中…