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Water → alpha-(2-Methylpropylidene)pyridine-2-acetonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Isobutyraldehyde | HCID 6561 | — |
| 反応物 | Piperidine | HCID 8082 | — |
| 反応物 | Pyridine-2-acetonitrile | HCID 75959 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 溶媒 | Benzene | HCID 241 | — |
| 生成物 | alpha-(2-Methylpropylidene)pyridine-2-acetonitrile | HCID 90767 | — |
反応手順
In a flask equipped with a water separator are placed 7 g of 2-pyridyl acetonitrile, 12.8 g of isobutyraldehyde, 0.9 ml of acetic acid, 0.18 ml of piperidine and 250 ml of dry benzene. The mixture is heated under reflux for 3 hours. After cooling, the reaction mixture is washed with water, the organic phase is dried over sodium sulfate then the solvent is evaporated to dryness.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04356177 |
| 出典データセット | uspto-grants-1982_10 |
| ORD ID | ord-8c24038a3fed4ea884fea50cdda5a581 |
| 出典メモ | uspto-grants-1982_10 |