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Imidazole → 7-{2-Butyl-4-[4-(4-methoxy-phenoxy)-phenyl]-imidazol-1-yl}-1,2,3,4-tetrahydro-isoquinoline hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Imidazole | HCID 795 | — |
| 反応物 | Urea | HCID 1176 | — |
| 反応物 | Valeryl chloride | HCID 61186 | — |
| 反応物 | Carbonyl bromide | HCID 79057 | — |
| 反応物 | 1-(4-(4-Methoxyphenoxy)phenyl)ethan-1-one | HCID 2777253 | — |
| 反応物 | tert-Butyl 7-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate | HCID 22061016 | — |
| 生成物 | 7-{2-Butyl-4-[4-(4-methoxy-phenoxy)-phenyl]-imidazol-1-yl}-1,2,3,4-tetrahydro-isoquinoline hydrochloride | HCID 66977535 | — |
反応手順
1-[4-(4-methoxyphenoxy)phenyl]ethan-1-one (1 mmol) was brominated by General Procedure R1. The bromo ketone was condensed with 7-amino-2-Boc-1,2,3,4-tetrahydroisoquinoline following general procedure R2. The aminoketone intermediate was treated with n-pentanoyl chloride accoding to General Procedure R3. The product amide was then subjected to imidazole formation employing general procedure R4. The BOC group of the product was removed employing general procedure T1 to afford 7-{2-butyl-4-[4-(4-methoxy-phenoxy)-phenyl]-imidazol-1-yl}-1,2,3,4-tetrahydro-isoquinoline hydrochloride (yield 135 mg)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07714013B2 |
| 出典データセット | uspto-grants-2010_05 |
| ORD ID | ord-3f22503a2e4643e79fa627d0fb889e26 |
| 出典メモ | uspto-grants-2010_05 |