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HRID 2237065作成日：2026年10月26日
4-Chloropyridine → [2-(4-{1-[4-(4-Chloro-phenoxy)-phenyl]-2-isobutyl-1H-imidazol-4-yl}-phenoxy)-ethyl]-pyridin-4-yl-amine
https://huagongshe.com/reaction/2237065
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 4-Chloropyridine | HCID 12288 | — |
| 反応物 | 2-(4-{1-[4-(4-Chloro-phenoxy)-phenyl]-2-isobutyl-1H-imidazol-4-yl}-phenoxy)-ethylamine | HCID 59699242 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | [2-(4-{1-[4-(4-Chloro-phenoxy)-phenyl]-2-isobutyl-1H-imidazol-4-yl}-phenoxy)-ethyl]-pyridin-4-yl-amine | HCID 59699105 | — |
反応手順
2-(4-{1-[4-(4-Chloro-phenoxy)-phenyl]-2-isobutyl-1H-imidazol-4-yl}-phenoxy)-ethylamine, the product of Example 512, was treated with 4-chloropyridine in DMF and was heated at 100° C. Aqueous workup and chromatography on silica gel afforded Example 519. (Yield: 80 mg)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07714013B2 |
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| 出典データセット | uspto-grants-2010_05 |
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| ORD ID | ord-5013b07f9c154b3fadfc49efd5d9de02 |
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| 出典メモ | uspto-grants-2010_05 |
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