5-Bromo-2-methyl-8-nitro-1,2,3,4-tetrahydroisoquinoline → 5-Bromo-2-methyl-1,2,3,4-tetrahydroisoquinolin-8-amine
反応式
[Br:1][C:2]1[CH:11]=[CH:10][C:9]([N+:12]([O-])=O)=[C:8]2[C:3]=1[CH2:4][CH2:5][N:6]([CH3:15])[CH2:7]2>C(O)C.[Ni]>[Br:1][C:2]1[CH:11]=[CH:10][C:9]([NH2:12])=[C:8]2[C:3]=1[CH2:4][CH2:5][N:6]([CH3:15])[CH2:7]2参加物
4
実験手順
To a solution of N-methyl-5-bromo-8-nitro-1,2,3,4-tetrahydroisoquinoline (III, 4.7 gm, 17.3 mmol) in ethanol (50 ml), Raney Nickel (solution in water, 1.5 g) was added. The reaction mixture was stirred at room temperature overnight under H2. The mixture was filtered through celite and solvent was removed under vacuum to give IV.
後処理
- filtrationThe mixture was filtered through celite and solvent
- customwas removed under vacuum
出典と根拠
- ORDレコード
- ord-7c5288c394f14f128e7b45d721e163bd
- 出典データセット
- uspto-grants-2010_05
- 特許番号
- US07718641B2
反応ノート
読み込み中…