4-(4-Amino-3-fluorophenyl)morpholin-3-one → 3-{[(5-Chloro-thiophene-2-carbonyl)-amino]-methyl}-[1,2,4]oxadiazole-5-carboxylic acid [4-(3-oxo-morpholin-4-yl)-phenyl]-amide
反応式
C(O[C:4]([C:6]1[O:10][N:9]=[C:8]([CH2:11][NH:12][C:13]([C:15]2[S:16][C:17]([Cl:20])=[CH:18][CH:19]=2)=[O:14])[N:7]=1)=[O:5])C.[NH2:21][C:22]1[CH:27]=[CH:26][C:25]([N:28]2[CH2:33][CH2:32][O:31][CH2:30][C:29]2=[O:34])=[CH:24][C:23]=1F>>[O:34]=[C:29]1[CH2:30][O:31][CH2:32][CH2:33][N:28]1[C:25]1[CH:24]=[CH:23][C:22]([NH:21][C:4]([C:6]2[O:10][N:9]=[C:8]([CH2:11][NH:12][C:13]([C:15]3[S:16][C:17]([Cl:20])=[CH:18][CH:19]=3)=[O:14])[N:7]=2)=[O:5])=[CH:27][CH:26]=1参加物
3
反応物 2
生成物 1
実験手順
In analogy to example 1E 3-{[(5-chloro-thiophene-2-carbonyl)-amino]-methyl}-[1,2,4]oxadiazole-5-carboxylic acid ethyl ester (example 1D) was reacted with 4-(4-amino-3-fluoro-phenyl)-morpholin-3-one (CAS 438056-69-0) to give 3-{[(5-chloro-thiophene-2-carbonyl)-amino]-methyl}-[1,2,4]oxadiazole-5-carboxylic acid [4-(3-oxo-morpholin-4-yl)-phenyl]-amide. Light yellow solid. MS 462.0 ([M+H]−)