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Benzene → N-acetyl-(R)-phenyl-alanine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzene | HCID 241 | — |
| 反応物 | 2-(Acetylamino)-3-phenyl-2-propenoic acid | HCID 95631 | — |
| 反応物 | HCID 178418361 | HCID 178418361 | — |
| 触媒 | cyclo-octadiene-((S)-1,2-Bis-(diphenylphosphino)-3-phenyl-propane)-rhodium-tetrafluoroborate | HCID 86738616 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | N-acetyl-(R)-phenyl-alanine | HCID 821174 | 99% |
反応手順
There were added saturated solution of α-acetamido cinnamic acid in a mixture of 2 parts by volume of ethanol and 1 part by volume of benzene 7.9 mg of the catalyst produced in Example 12. The reaction mixture was sucked into an evacuated 100 ml autoclave and pressurized with 17 bars of hydrogen pressure. After working up in the manner as described in Example 6, there were isolated 4.4 grams of N-acetyl-(R)-phenyl-alanine having a rotary value of [α]D20 =-46.5° (c=1/95% EtOH), corresponding to an optical yield of 99%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04356324 |
| 出典データセット | uspto-grants-1982_10 |
| ORD ID | ord-008c63fd9da74710bae5d9f2cc8ef5fc |
| 出典メモ | uspto-grants-1982_10 |