1-{Imidazo[1,2-a]pyridin-3-yl}ethan-1-one → HCID 59176797、化合物

HRID 2238630ノート

反応式

HRID 2238630 の反応式
[N:1]1[CH:2]=[C:3]([C:10](=[O:12])[CH3:11])[N:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=12>COC(OC)N(C)C>[CH3:3][N:4]([CH3:9])/[CH:5]=[CH:11]/[C:10]([C:3]1[N:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]2=[N:1][CH:2]=1)=[O:12]

参加物

3

反応物 1

HCID 157181821-{Imidazo[1,2-a]pyridin-3-yl}ethan-1-one

生成物 1

HCID 59176797HCID 59176797、化合物

試薬・触媒・溶媒 1

HCID 78373Dimethylformamide dimethyl acetal溶媒

実験手順

Unpurified imidazo[1,2-a]pyridin-3-ylethanone [1-1] was dissolved in 400 mL of N,N-dimethylformamide dimethylacetal, and overheated overnight under reflux. The dimethylformamide dimethylacetal was distilled off under reduced pressure, and then diethyl ether was added to the residue. Thus obtained solid was separated by filtration and dried under reduced pressure, to obtain 5.06 g of (E)-3-(dimethylamino)-1-imidazo[1,2-a]pyridin-3-yl-2-propen-1-one [1-2] as a light brown solid.

後処理

  1. temperatureoverheated overnight under reflux
  2. distillationThe dimethylformamide dimethylacetal was distilled off under reduced pressure
  3. additiondiethyl ether was added to the residue
  4. customThus obtained solid was separated by filtration
  5. customdried under reduced pressure

出典と根拠

ORDレコード
ord-938b73aebbd24a2eaaab8319abce0f70
出典データセット
uspto-grants-2010_05
特許番号
US07718801B2

反応ノート

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