HCID 178472436、化合物 → HCID 178472435、化合物
反応式
[ClH:1].[NH2:2][C@H:3]1[CH2:8][CH2:7][C@H:6]([C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH2:5][CH2:4]1.N[C@H]1CC[C@H](C(O)=O)CC1>>[ClH:1].[CH2:12]([O:11][C:9]([C@H:6]1[CH2:7][CH2:8][C@@H:3]([NH2:2])[CH2:4][CH2:5]1)=[O:10])[CH3:13]参加物
3
実験手順
19.3 mL of concentrated hydrochloric acid (2.8 eq) was added to a solution of cis-4-aminocyclohexane carboxylic acid (10 g, 69.83 mmol) in anhydrous ethyl alcohol (250 mL). Mixture was stirred overnight at about 60° C. and then cooled to room temperature. Solvent was evaporated in vacuo. Crude material was then redissolved in acetonitrile, sonicated, and concentrated to a solid in vacuo. This acetonitrile wash was repeated three times to obtain 11.5 g of while solid (96% yield). Trans-ethyl 4-aminocyclohexanecarboxylate hydrochloride can be prepared following the same procedure using trans-4-aminocyclohexane carboxylic acid.
出典と根拠
- ORDレコード
- ord-cbdff9c45a51451fbd0caa7bc358d1a3
- 出典データセット
- uspto-grants-2010_05