2-Furancarboxylic acid, hydrazide → N'-(2-amino-7H-pyrrolo[2,3-d]pyrimidin-4-yl)furan-2-carbohydrazide

HRID 2239805ノート

反応式

HRID 2239805 の反応式
Cl[C:2]1[C:3]2[CH:11]=[CH:10][NH:9][C:4]=2[N:5]=[C:6]([NH2:8])[N:7]=1.[O:12]1[CH:16]=[CH:15][CH:14]=[C:13]1[C:17]([NH:19][NH2:20])=[O:18]>C(O)CCC>[NH2:8][C:6]1[N:7]=[C:2]([NH:20][NH:19][C:17]([C:13]2[O:12][CH:16]=[CH:15][CH:14]=2)=[O:18])[C:3]2[CH:11]=[CH:10][NH:9][C:4]=2[N:5]=1

参加物

4

反応物 2

HCID 187312-Furancarboxylic acid, hydrazideHCID 53244134-chloro-7H-pyrrolo(2,3-d)pyrimidin-2-amine

生成物 1

HCID 68413686N'-(2-amino-7H-pyrrolo[2,3-d]pyrimidin-4-yl)furan-2-carbohydrazide

試薬・触媒・溶媒 1

HCID 2631-Butanol溶媒

反応条件

温度
120 °C

実験手順

4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-2-amine (0.5 g, 2 96 mmol) and 2-furoic acid hydrazide (0.76 g, 6.0 mmol) are taken into 30 mL of n-butanol. The mixture is stirred at 120° C. under N2 for 2 h. The solvent is evaporated in vacuum and the residue is triturated with water and filtered to afford compound N′-(2-amino-7H-pyrrolo[2,3-d]pyrimidin-4-yl)furan-2-carbohydrazide: LC/MS (M+1=259.32). This material is used in the next step without further purification.

後処理

  1. customThe solvent is evaporated in vacuum
  2. customthe residue is triturated with water
  3. filtrationfiltered

出典と根拠

ORDレコード
ord-c504f7736a544ef0a1f5bda51ed03146
出典データセット
uspto-grants-2010_05
特許番号
US07723343B2

反応ノート

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