N1-(6-chloroimidazo[1,2-b]pyridazin-8-yl)benzene-1,4-diamine → HCID 178507709、化合物

HRID 2239849ノート

反応式

HRID 2239849 の反応式
Cl[C:2]1[CH:3]=[C:4]([NH:11][C:12]2[CH:17]=[CH:16][C:15]([NH2:18])=[CH:14][CH:13]=2)[C:5]2[N:6]([CH:8]=[CH:9][N:10]=2)[N:7]=1.[NH2:19][C@H:20]1[CH2:25][CH2:24][C@H:23]([NH2:26])[CH2:22][CH2:21]1>O>[NH2:19][C@H:20]1[CH2:25][CH2:24][C@H:23]([NH:26][C:2]2[CH:3]=[C:4]([NH:11][C:12]3[CH:17]=[CH:16][C:15]([NH2:18])=[CH:14][CH:13]=3)[C:5]3[N:6]([CH:8]=[CH:9][N:10]=3)[N:7]=2)[CH2:22][CH2:21]1

参加物

4

反応物 2

HCID 86611734N1-(6-chloroimidazo[1,2-b]pyridazin-8-yl)benzene-1,4-diamineHCID 178511674HCID 178511674、化合物

生成物 1

HCID 178507709HCID 178507709、化合物収率 154%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To N1-(6-chloroimidazo[1,2-b]pyridazin-8-yl)benzene-1,4-diamine (0.2 g, 0.77 mmol) from 1a was added trans-1,4-diaminocyclohexane (1.7 g, 15.0 mmol). The mixture was allowed to melt at 160° C. for 3 days. The melt was then cooled, diluted with water and extracted with dichloromethane. The organic layer was then concentrated in vacuo to give 0.4 g of crude N6-(trans-4-aminocyclohexyl)-N8-(4-aminophenyl)imidazo[1,2-b]pyridazine-6,8-diamine.

後処理

  1. temperatureThe melt was then cooled
  2. extractionextracted with dichloromethane
  3. concentrationThe organic layer was then concentrated in vacuo

出典と根拠

ORDレコード
ord-053eba1c98d54a539d863e5c0eb6f505
出典データセット
uspto-grants-2010_05
特許番号
US07723336B2

反応ノート

読み込み中…